The breakthroughs were performed by separate systems, but show how the powerful technology’s uses go far beyond the generation of images and text.
University of Toronto researchers worked with Insilico Medicine to develop potential treatment for hepatocellular carcinoma (HCC) using an AI drug discovery platform called Pharma.
HCC is a form of liver cancer, but the AI discovered a previously unknown treatment pathway and designed a ‘novel hit molecule’ that could bind to that target.
The system, which can also predict survival rate, is the invention of scientists from the University of British Columbia and B.C. Cancer, who found the model is 80 percent accurate.
AI is becoming the new weapon against deadly diseases, as the technology is capable of analyzing vast amounts of data, uncovering patterns and relationships and predicting effects of treatments.
Insilico Medicine founder and CEO Alex Zhavoronkov said in a statement: ‘While the world was fascinated with advances in generative AI in art and language, our generative AI algorithms managed to design potent inhibitors of a target with an AlphaFold-derived structure.’
The team used AlphaFold, an artificial intelligence (AI)-powered protein structure database, to design and synthesize a potential drug to treat hepatocellular carcinoma (HCC), the most common type of primary liver cancer.
The feat was accomplished in just 30 days from target selection and after only synthesizing seven compounds.
In a second round of AI-powered compound generation, researchers discovered a more potent hit molecule – although any potential drug would still need to undergo clinical trials.
Feng Ren, chief scientific officer and co-CEO of Insilico Medicine, said: ‘AlphaFold broke new scientific ground in predicting the structure of all proteins in the human body.
‘At Insilico Medicine, we saw that as an incredible opportunity to take these structures and apply them to our end-to-end AI platform in order to generate novel therapeutics to tackle diseases with high unmet need. This paper is an important first step in that direction.’
Daily mail.
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