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US Surgeons Perform World’s First Whole Eye Transplant

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A team of surgeons in New York announced Thursday they had performed the world’s first transplant of an entire eye in a procedure widely hailed as a medical breakthrough, although it isn’t yet known whether the recipient will actually regain his sight.

The groundbreaking surgery involved removing part of the face and the whole left eye of a donor and grafting them onto a line worker from Arkansas who survived a 7,200-volt electric shock in June 2021, when his face touched a live wire.

Aaron James, 46, suffered extensive injuries including the loss of his left eye, his dominant left arm above the elbow, his nose and lips, front teeth, left cheek area and chin.

He was referred to NYU Langone Health, a leading medical center for facial transplants, which carried out the procedure on May 27.

Transplanting an entire eye has long been a holy grail of medical science, and though researchers have had some success in mice — where they have restored partial vision — it’s never before been performed in a living person.

“We always talk about a second chance at life — he’s been given a second chance,” said Eduardo Rodriguez, who led the 21-hour-surgery that made use of 3D cutting guides, which allowed surgeons to remove segments of bone from the donor and place them precisely in James.

“We couldn’t have asked for a more perfect patient,” he added, praising James for undergoing the extremely risky surgery so that others in his situation could benefit in the future.

The transplanted left eye appears very healthy, said retinal opthamologist Vaidehi Dedania. It has a good blood supply, is maintaining its pressure, and is generating an electrical signal, though James is not yet able to see. “But we have a lot of hope,” she added.

– ‘Huge deal’ –

“This is a huge deal,” Kia Washington, a professor of surgery at University of Colorado Anschutz Medical Campus, who has been working in the same field for 15 years, told AFP, commending her peers.

Daniel Pelaez of the University of Miami’s Bascom Palmer Eye Institute, who has also been working towards the same goal, told AFP: “The transplantation of a human eye at NYU Langone represents a pivotal moment in our common quest to restore sight and offers hope to countless individuals around the world.”

James, whose right eye remains intact, was considered an ideal candidate because his need for a facial transplant meant he would require immunosuppressive drugs regardless, making the risk-benefit calculation favorable — even if it conferred only cosmetic value.

Appearing at a press conference, James expressed his profound gratitude to both the donor’s family and his medical team. “It’s been a test of willpower, strength, family, friends, and I think we beat it,” he said.

James returned to his native Arkansas in September to be with his wife and daughter but returns to New York for monthly follow-up appointments.

– Optic nerve regeneration –

Given the time that has passed since the surgery, Washington said she did not think it likely that James’s eye would regain vision, but “I never say something is impossible,” she added.

The NYU Langone team said they had used bone marrow-derived adult stem cells to promote nerve repair.

Achieving the goal of sight restoration could involve bringing other cutting-edge approaches to bear, said Washington — including gene therapy to tap the optic nerve’s intrinsic ability to heal; using a device called a nerve wrap to protect the tissue; or using devices that pick up signals and bypass the damaged pathway.

“We’re making great progress in the treatments to promote optic nerve regeneration that could accompany eye transplant,” Jeffrey Goldberg, who is leading similar efforts at the Byers Eye Institute at Stanford University, told AFP.

“These adjunctive therapies will allow the donor eye to significantly connect to the brain and restore meaningful visual function to blind patients everywhere.”

 

 

 

 

 

AFP

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UK Teenagers To Trial Social Media Bans, Digital Curfews

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Hundreds of British teenagers will trial social media bans and time limits on apps as part of consultations over new measures to keep children safe online, the government announced Wednesday.

 

The pilot comes as the government seeks views from parents on whether to follow Australia and issue a blanket ban on social media for children under 16.

Three hundred youngsters aged 13 to 17 will try out different restrictions on social media use over six weeks to gauge the impact on their schoolwork, sleep and family life.

Some will have their social media apps disabled entirely, while others will have no access to them overnight, said the Department for Science, Innovation and Technology.

[ A young student uses her mobile phone at a public school in Planaltina

A third group will have a one-hour-per-day cap on the most popular apps for teenagers, including Instagram, TikTok and Snapchat.

The results will be compared to a fourth set of children who will continue to receive unlimited access.

“We are determined to give young people the childhood they deserve and to prepare them for the future,” said technology minister Liz Kendall.

“These pilots will give us the evidence we need to take the next steps, informed by the experiences of families themselves.”

Australia in December became the first nation to prohibit people under the age of 16 from using immensely popular and profitable social media platforms.

Several other countries are considering similar bans, including France where lawmakers in January passed a bill that would prohibit use by under-15s, which still needs final approval.

A boy poses at his home as he looks at social media on his tablet

The British government has launched a consultation on a potential Australia-style ban, which will also look at measures including age restrictions and banning addictive features like scrolling.

Earlier this month, British MPs struck down proposals by the upper House of Lords chamber to ban social media for under-16s while it awaits the outcome of the consultation, due to close on May 26.

British public figures including actor Hugh Grant have urged the government to back a prohibition, saying parents alone cannot counter social media harms.

But some experts warn restrictions could be easily circumvented and would rather that tech platforms focus on making their sites safer.

Labour Prime Minister Keir Starmer has not ruled out a ban.

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Israel Defence Minister Says Iran Guards Navy Commander Killed In Strike

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Defence Minister Israel Katz announced on Thursday that an Israeli airstrike had killed Alireza Tangsiri, commander of the Iranian Revolutionary Guards’ navy.

“Last night, in a precise and lethal operation, the IDF eliminated the commander of the Revolutionary Guards’ navy, Tangsiri, along with senior officers of the naval command,” Katz said in a video statement.

“The man who was directly responsible for the terrorist operation of mining and blocking the Strait of Hormuz to shipping was blown up and eliminated.”

Since the start of the joint US-Israeli attacks on Iran on February 28, Israel has announced the killing of several top Iranian officials, including supreme leader Ali Khamenei and the Islamic republic’s powerful security chief, Ali Larijani.

In recent days, Israeli forces have carried out several strikes targeting the naval assets of Iran.

Last week, Israeli airstrikes hit several Iranian naval ships in the Caspian Sea, including ones equipped with missile systems, support vessels and patrol craft.

 

 

 

 

 

 

AFP

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Iran ‘Afraid’ To Admit It Wants A Deal, Says Trump

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US President Donald Trump insisted Wednesday that Iran was taking part in peace talks, suggesting Tehran’s denials were because Iranian negotiators fear being killed by their own side.

“They are negotiating, by the way, and they want to make a deal so badly. But they’re afraid to say it, because they figure they’ll be killed by their own people,” Trump told a dinner for Republican members of Congress.

“They’re also afraid they’ll be killed by us.”

The US leader’s comments came after Iranian Foreign Minister Abbas Araghchi said that “we do not intend to negotiate”.

Trump repeated his assertion that Iran was being “decimated” in the conflict now in its fourth week, even though Tehran still maintains an effective stranglehold over the crucial Strait of Hormuz oil route.

Lashing out at his domestic opponents, Trump also claimed Democrats were trying to “deflect from all of the tremendous success that we’re having in this military operation.”

In a mocking reference to calls from Democrats for him to seek the approval of Congress for the conflict, Trump added: “They don’t like the word ‘war,’ because you’re supposed to get approval, so I’ll use the word military operation.”

The White House said earlier that Trump was ready to “unleash hell” if Iran did not admit defeat, while also insisting that Tehran is still taking part in talks.

Iranian state media had earlier cited an unidentified official as saying that the Islamic republic had responded “negatively” to a reported 15-point plan from Washington.

 ‘Talks continue’

“If Iran fails to accept the reality of the current moment, if they fail to understand that they have been defeated militarily and will continue to be, President Trump will ensure they are hit harder than they have ever been hit before,” Press Secretary Karoline Leavitt told reporters.

“President Trump does not bluff and he is prepared to unleash hell. Iran should not miscalculate again.”

Asked if negotiations with Iran had stalled, Leavitt replied: “Talks continue. They are productive.”

Leavitt declined to say whom the US was dealing with in Tehran following the assassination of supreme leader Ali Khamenei, whose son and successor Mojtaba Khamenei has not been seen in public.

Reports have suggested the Trump administration’s interlocutor is Mohammad Bagher Ghalibaf, Iran’s speaker of parliament and one of its most prominent non-clerical figures.

The spokeswoman also declined to confirm reports that top US officials including Vice President JD Vance were set to hold talks with the Iranians in Pakistan, which has emerged as a key mediator.

Trump is moving thousands of airborne troops and extra marines to the Gulf amid speculation that he might order a ground invasion to either seize Iranian oil assets in the Gulf or secure the Strait of Hormuz.

The White House meanwhile appeared to stick to the four to six-week timeline it has previously given for the war.

Trump announced Wednesday that his visit to China to meet Xi Jinping had now been rescheduled for mid-May, having postponed it by six weeks to deal with the conflict.

“We’ve always estimated approximately four to six weeks (for the length of military operations against Iran), so you could do the math on that,” Leavitt added.

 

 

 

 

 

AFP

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